GLYCOLYSIS AND GLUTATHIONE
نویسندگان
چکیده
منابع مشابه
Xcv. Role of Glutathione in Anaerobic Tissue Glycolysis
THE relative amounts of lactic acid produced anaerobically by animal tissues from glycogen and from glucose depend on the tissue. Skeletal muscles, while able to form a large quantity of lactic acid from glycogen, produce only a relatively small amount of lactic acid from glucose. On the other hand involuntary muscles, brain tissue, heart muscle and lungs produce far more lactic acid from gluco...
متن کاملDifferential Effects of Iodoacetamide and Iodoacetate on Glycolysis and Glutathione Metabolism of Cultured Astrocytes
Iodoacetamide (IAA) and iodoacetate (IA) have frequently been used to inhibit glycolysis, since these compounds are known for their ability to irreversibly inhibit the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH). However, the consequences of a treatment with such thiol reagents on the glutathione (GSH) metabolism of brain cells have not been explored. Exposure of astrogli...
متن کاملBlocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.
Myc oncoproteins induce genes driving aerobic glycolysis, including lactate dehydrogenase-A that generates lactate. Here, we report that Myc controls transcription of the lactate transporter SLC16A1/MCT1 and that elevated MCT1 levels are manifest in premalignant and neoplastic Eμ-Myc transgenic B cells and in human malignancies with MYC or MYCN involvement. Notably, disrupting MCT1 function lea...
متن کاملAerobic glycolysis and lymphocyte transformation.
1. The role of enhanced aerobic glycolysis in the transformation of rat thymocytes by concanavalin A has been investigated. Concanavalin A addition doubled [U-(14)C]glucose uptake by rat thymocytes over 3h and caused an equivalent increased incorporation into protein, lipids and RNA. A disproportionately large percentage of the extra glucose taken up was converted into lactate, but concanavalin...
متن کاملGlycolysis, glutaminolysis and cell proliferation.
Since the original observation that a high rate of aerobic glycolysis is a hallmark of malignant cells (Warburg, 1926), considerable effort has been devoted to elucidation of the role of glycolysis in normal and transformed cell proliferation. Many explanations have been put forward to explain the high flux of glucose to lactate in proliferating normal and transformed cells (Warburg, 1926; Papa...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1938
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)74149-5